Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 3

Conference Videos 1

Year

2023 4

Keywords

2-DG 1

CPAL 1

Inflammation 1

Myocardial infarction 1

NFκB 1

Pyroptosis 1

dry eye disease 1

glycolytic reprogramming 1

inflammation 1

pyroptosis 1

open ︾

Search scope:

排序： Display mode:

A new perspective in pyroptosis: lifting the veil on GSDMA activation

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 581-583 doi: 10.1007/s11684-022-0971-9

Abstract: . {{custom_ra.content}} . . . {{article.highlightEn}} . . . {{article.abstractEn}} . . . {{article.authorSummayEn}} . . . . .

HTML PDF Collect

Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 781-795 doi: 10.1007/s11684-023-0986-x

Abstract: mechanisms involving the hyperosmolar microenvironment, glycolysis mediating metabolic reprogramming, and pyroptosisData from DED clinical samples indicated that the expression of glycolysis and pyroptosis-related genesexpression. 2-Deoxy-d-glucose (2-DG) could inhibit the glycolysis of HCECs and subsequently suppress the pyroptosisactivity and could significantly reduce the overexpression of genes and proteins related to glycolysis and pyroptosishyperosmolar-induced glycolytic reprogramming played an active role in promoting DED inflammation by mediating pyroptosis

Keywords： dry eye disease glycolytic reprogramming pyroptosis inflammation 2-DG

HTML PDF Collect

CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Article

Jiamin Li, Hongru Xue, Ning Xu, Liling Gong, Ming Li, Sijia Li, Di Huang, Qingwei Zhang, Pengyu Li, Qingsui Li, Hang Yu, Yining Liu, Yadong Xue, Haixin Chen, Jiali Liu, Wanyu Zhang, Mingbin Liu, Siyu Chang, Xianzhi Lang, Xingmiao Zhao, Weijie Du, Benzhi Cai, Ning Wang, Baofeng Yang

Engineering 2023, Volume 20, Issue 1, Pages 49-62 doi: 10.1016/j.eng.2022.08.012

Abstract: hexokinase 1 (HK1), and glucose transporter 4 (GLUT4), accompanied by cardiomyocyte pyroptosisWe then identify a previously unknown conserved lncRNA, AK009126 (cardiomyocyte pyroptosis-associatedits short hairpin RNA (shRNA) partially abrogates myocardial metabolic alterations and cardiomyocyte pyroptosisreveal the conserved lncRNA CPAL as a new regulator of cardiac metabolic abnormalities and cardiomyocyte pyroptosis

Keywords： Myocardial infarction Pyroptosis CPAL NFκB Inflammation